Generative Data Intelligence

Stem Cell

Luspatercept for the treatment of anemia in allo-HSCT for patients with hematological diseases

Dear Editor,Anemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a common complication, which is characterized by hemoglobin levels below the normal range, accompanied...

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CIRM invests nearly $44 million to advance regenerative medicine research and manufacturing in California

September 29, 2023 South San Francisco, CA –  The California Institute for Regenerative Medicine (CIRM), the world’s largest institution dedicated to regenerative medicine,...

Perivascular niche cells sense thrombocytopenia and activate hematopoietic stem cells in an IL-1 dependent manner – Nature Communications

Acute platelet depletion rapidly recruits quiescent HSCs into proliferationIn line with previous studies9, administration of a single dose of anti-GPIbα antibody to Vwf-GFP mice,...

BrainStorm Cell Therapeutics Hail Mary with FDA on Nurown for ALS – The Niche

BrainStorm Cell Therapeutics is developing Nurown, an investigational therapy intended for treating ALS. I recently posted about BrainStorm and its prospects for providing real hope...

Aberrant differentiation of epithelial progenitors is accompanied by a hypoxic microenvironment in the paraquat-injured human lung – Cell Discovery

Dear Editor,Paraquat is a toxic herbicide that can cause severe lung injury, leading to alveolar epithelial cell death, subsequent lung fibrosis and respiratory failure....

What Is Intracranial Hypertension And How Is It Connected To The Neck?

Nowadays, more and more people are dealing with neck pain and headaches. There are a lot of different causes of neck pain and headaches,...

Human embryo models offer glimpse into early development

RESEARCH HIGHLIGHT 25 September 2023 Grown from stem cells, the models recapitulate the hallmarks of post-implantation human embryos up to...

Weekly reads: artificial wombs, mice with rat brains, Neuralink – The Niche

It feels like we are marching towards a future in which key aspects of human reproduction, including the use of artificial wombs, could be...

Abnormal developmental trajectory and vulnerability to cardiac arrhythmias in tetralogy of Fallot with DiGeorge syndrome – Communications Biology

Generation and characterisation of patient-specific hiPSCs and hiPSC-CMshiPSC lines were established from two TOF-DG patients, two TOF-ND patients, and two healthy controls with pluripotency...

C9orf72-ALS human iPSC microglia are pro-inflammatory and toxic to co-cultured motor neurons via MMP9 – Nature Communications

Ethics statementAll iPSC lines were previously derived from skin biopsy fibroblasts, following signed informed consent, collected under ethical approval granted by the South Wales...

Burst Biologics unapproved biologic used by Weill Cornell: was there a cover-up? – The Niche

The New York Times just broke a story on Burst Biologics and Weill Cornell that fits with long-standing troubling questions about regenerative biologics producers....

Long non-coding RNA SNHG8 drives stress granule formation in tauopathies – Molecular Psychiatry

Bodea LG, Eckert A, Ittner LM, Piguet O, Götz J. Tau physiology and pathomechanisms in frontotemporal lobar degeneration. J Neurochem. 2016;138:71–94.Article  CAS  PubMed  PubMed...

Defining epigenetic reprogramming, cellular reprogramming & rejuvenation – The Niche

Epigenetic reprogramming is a term used in cell biology that is increasingly ending up in news stories too. Unfortunately, some folks, especially in the cellular...

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