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Coya Therapeutics Announces Positive Interim Results of an Investigator-Initiated Open Label Study with Low-Dose IL-2 and CTLA4-Ig Combination Treatment in Five Patients with Mild to Moderate Frontotemporal Dementia

  • Results from the first patient cohort (N=5) of an open-label proof of concept academic study with low-dose IL-2 and CTLA4-Ig demonstrated a rapid and durable statistically significant increase in the number and suppressive function of Tregs compared to baseline values.
  • Clinically, patients with Frontotemporal Dementia (FTD) demonstrated minimal to no cognitive decline throughout the study period. Treatment was well tolerated, no serious adverse events were reported, and all 5 patients completed the study.

HOUSTON, TX, April 24, 2025 — Coya Therapeutics, Inc. (NASDAQ: COYA) (“Coya” or the “Company”), a clinical-stage biotechnology company developing biologics intended to enhance regulatory T cell (Treg) function announced positive interim results of an investigator-initiated proof of concept open-label study with low-dose IL-2 and CTLA4-Ig combination treatment in patients with Frontotemporal Dementia (FTD). The study is led by Dr. Alireza Faridar and Dr. Stanley Appel at the Houston Methodist Neurological Institute (Houston, TX) with funding from The Peggy and Gary Edwards Endowment Fund. Study patients received subcutaneously administered CTLA4-Ig, followed by a 5-day course of low-dose IL-2 every four weeks, for a total of 22 weeks of dosing and follow-up. The study aims to enroll up to 10 patients, and these interim results include data from the first 5 patients with mild to moderate FTD who have completed the full course of treatment.

Dr. Arun Swaminathan, Coya’s Chief Executive Officer followed: “The results thus far are consistent with previously published encouraging data from an open-label investigator-initiated study of patients with ALS treated with low-dose IL-2/CTLA4-Ig. This interim data in FTD provides us further confidence of our approach to target and enhance Treg biology to address devastating neurodegenerative diseases including ALS and FTD”.

Previous biomarker data presented by the Company demonstrated that FTD patients exhibit a compromised immunosuppressive function of regulatory T cells (Tregs), along with increased peripheral levels of inflammatory cytokines and chemokines, dysregulation of monocytes, and systemic activation of the inflammatory cascade, supporting the critical role of the immune system in the pathophysiology of FTD.

One previous study showed that a cohort of 68 patients with FTD worsened by an average of 3.57 points over a 12-month period per the Clinical Dementia Rating – Frontotemporal Lobar Degeneration (CDR‐FTLD) scale (Knopman et al. Brain 2008; 131(11): 2957-2968). In addition, patients with FTD typically have shorter survival times and more rapid rates of cognitive and functional decline compared to patients with Alzheimer’s disease (Rascovsky et al. Neurology 2005; 65(3): 397-403).

Dr. Fred Grossman, Coya’s Chief Medical Officer stated: “We are excited with the results observed in this initial group of patients with this proof-of-concept study. We believe that the increase in Treg numbers and suppressive function, with subsequent anti-inflammatory biological activity still to be evaluated, underscores the potential for this low-dose IL-2/CTLA4-Ig combination to be further studied as a therapy for FTD, for which there are no currently approved treatments.”

Summary of Interim Study Results

Overall, treatment with low-dose IL-2 and CTLA4-Ig was well tolerated. All 5 patients enrolled in the first cohort completed the study and received the investigational treatment as planned. The most common adverse events were mild injection site reactions. No serious adverse events were reported.

Treg numbers and suppressive function increased after the first treatment cycle (p < 0.01 and p < 0.05, respectively, and remained at higher significant levels throughout the treatment period.

Clinical functional assessments were performed in all patients at pre-specified timepoints over the course of the study using validated tools, including the Clinical Dementia Rating – Frontotemporal Lobar Degeneration (CDR‐FTLD) scale, the Montreal Cognitive Assessment (MoCA) scale, and the Progressive Aphasia Severity Scale (PASS). Results of the functional tests show that, on average, these five FTD patients treated with low-dose IL-2 and CTLA4-Ig combination exhibited minimal to no cognitive decline over the course of the study, compared to pre-treatment values.

The Company intends to publish and/or present more comprehensive data in a future peer-reviewed meeting and/or publication.

About Frontotemporal Dementia

Frontotemporal dementia (FTD) refers to a group of neurodegenerative disorders characterized by altered behavior and language, with a progressive decline in executive function.1 FTD affects an estimated 30,000 Americans.2 FTD is categorized clinically into various subtypes; the main three include behavioral-variant frontotemporal dementia and two language variants, semantic dementia (also known as semantic variant primary progressive aphasia) and progressive non-fluent aphasia (also known as non-fluent variant primary progressive aphasia). It’s a presenile dementia, meaning it can occur in younger individuals, often between the ages of 45 and 64. The average age of onset is 58, with an average survival time of 7.5 years.1,2

References

  1. Knopman et al. Development of methodology for conducting clinical trials in frontotemporal lobar degeneration. Brain 2008; 131(11): 2957-2968
  2. Rascovsky et al. Rate of progression differs in frontotemporal dementia and Alzheimer disease. Neurology 2005; 65(3): 397-403

About Coya Therapeutics, Inc.

Headquartered in Houston, TX, Coya Therapeutics, Inc. (Nasdaq: COYA) is a clinical-stage biotechnology company developing proprietary treatments focused on the biology and potential therapeutic advantages of regulatory T cells (“Tregs”) to target systemic inflammation and neuroinflammation. Dysfunctional Tregs underlie numerous conditions, including neurodegenerative, metabolic, and autoimmune diseases, and this cellular dysfunction may lead to sustained inflammation and oxidative stress resulting in lack of homeostasis of the immune system.

Coya’s investigational product candidate pipeline leverages multiple therapeutic modalities aimed at restoring the anti-inflammatory and immunomodulatory functions of Tregs. Coya’s therapeutic platforms include Treg-enhancing biologics, Treg-derived exosomes, and autologous Treg cell therapy.

COYA 302 is a combination treatment comprised of low-dose IL-2 and CTLA4-Ig is an investigational therapy with a dual immunomodulatory mechanism of action intended to enhance the anti-inflammatory function of Tregs and suppress the inflammation produced by activated monocytes and macrophages. Coya is developing COYA 302 for the treatment of fatal neurogenerative diseases characterized by chronic inflammation and Treg dysfunction.

For more information about Coya, please visit www.coyatherapeutics.com

Forward-Looking Statements

This press release contains “forward-looking” statements that are based on our management’s beliefs and assumptions and on information currently available to management. Forward-looking statements include all statements other than statements of historical fact contained in this presentation, including information concerning our current and future financial performance, business plans and objectives, current and future clinical and preclinical development activities, timing and success of our ongoing and planned clinical trials and related data, the timing of announcements, updates and results of our clinical trials and related data, our ability to obtain and maintain regulatory approval, the potential therapeutic benefits and economic value of our product candidates, competitive position, industry environment and potential market opportunities. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” and similar expressions are intended to identify forward-looking statements.

Forward-looking statements are subject to known and unknown risks, uncertainties, assumptions and other factors including, but not limited to, those related to risks associated with the success, cost and timing of our product candidate development activities and ongoing and planned clinical trials; our plans to develop and commercialize targeted therapeutics; the progress of patient enrollment and dosing in our preclinical or clinical trials; the ability of our product candidates to achieve applicable endpoints in the clinical trials; the safety profile of our product candidates; the potential for data from our clinical trials to support a marketing application, as well as the timing of these events; our ability to obtain funding for our operations; development and commercialization of our product candidates; the timing of and our ability to obtain and maintain regulatory approvals; the rate and degree of market acceptance and clinical utility of our product candidates; the size and growth potential of the markets for our product candidates, and our ability to serve those markets; our commercialization, marketing and manufacturing capabilities and strategy; future agreements with third parties in connection with the commercialization of our product candidates; our expectations regarding our ability to obtain and maintain intellectual property protection; our dependence on third party manufacturers; the success of competing therapies or products that are or may become available; our ability to attract and retain key scientific or management personnel; our ability to identify additional product candidates with significant commercial potential consistent with our commercial objectives; ; and our estimates regarding expenses, future revenue, capital requirements and needs for additional financing.

We have based these forward-looking statements largely on our current expectations and projections about future events and trends that we believe may affect our financial condition, results of operations, business strategy, short-term and long-term business operations and objectives, and financial needs. Moreover, we operate in a very competitive and rapidly changing environment, and new risks may emerge from time to time. It is not possible for our management to predict all risks, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements we may make. In light of these risks, uncertainties and assumptions, the forward-looking events and circumstances discussed herein may not occur and actual results could differ materially and adversely from those anticipated or implied in the forward-looking statements. Although our management believes that the expectations reflected in our forward-looking statements are reasonable, we cannot guarantee that the future results, levels of activity, performance or events and circumstances described in the forward-looking statements will be achieved or occur. We undertake no obligation to publicly update any forward-looking statements, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

Investor Contact
David Snyder, CFO
david@coyatherapeutics.com

CORE IR
Bret Shapiro
brets@coreir.com

561-479-8566

Media Contacts
For Coya Therapeutics:

Kati Waldenburg

media@coyatherapeutics.com

212-655-0924

Holland Casino in Peril Amid Increasing Gaming Taxes

Holland Casino in Peril Amid Increasing Gaming Taxes

Holland Casino, the Netherlands’ state-owned casino operator, has once again opposed the country’s plans to raise the gambling tax. Dutch lawmakers set out to gradually increase the gambling tax, despite the operator’s numerous warnings.

Holland Casino Is Unhappy with the Rising Tax

For context, the Netherlands decided to incrementally increase its gambling from 30.5% to 34.2% in January 2025. The tax should reach 37.8% by 2026, marking a total increase of over seven percent.

Holland Casino’s latest report cast doubt on the company’s ability to operate sustainably, which was further exacerbated by the Netherlands’ tax plans. The report highlighted significant material uncertainty, necessitating significant changes if the company is to be able to continue operating into 2027.

For context, Holland Casino reported EUR 10.4 million in losses for 2024, highlighting its precarious position. Although the company welcomed more guests than the year before, customers spent less on each visit, resulting in an overall loss for the company.

As if that wasn’t serious enough, Holland Casino’s online branch also saw its revenues decline amid strong competition from the regulated Dutch iGaming market.

Holland Casino Is Considering a Variety of Measures

At the same time, taxes and the overall costs of living and conducting a business have continued to mount up, putting Holland Casino in a difficult position. With higher taxes on the horizon, Holland Casino plans to introduce various changes in the way it conducts business in order to remain operational.

These include an overall workforce reorganization, which has already seen Holland Casino lay off hundreds of workers at its HQ. In addition to that, the company has closed its casino in Zandvoort and could potentially put an end to other less profitable locations.

This would mirror the move of JVH Gaming & Entertainment, the parent company of popular online casino brands Jack’s Casino, Flash Casino, and Flamingo Casino, which opted to close a whopping 23 venues because of the tax hike and regulatory headwinds.

In the meantime, Holland Casino is currently experimenting with lower chances at roulette. It is also eyeing digitalization measures that would lead to further cost savings.

In any case, Holland Casino refused to comment on its exact plans to reduce costs and deal with the upcoming tax hike. However, it insisted that the availability of legal gaming services is paramount to providing customers with ways to play responsibly.

The 2024 Gaming Tax Reached Unprecedented Heights

A month ago, the Netherlands’ Centraal Bureau voor de Statistiek, said that in 2024, legal gaming operators paid an unprecedented total of EUR 1 billion in taxes. Despite reflecting the period before the recent tax increases, these results highlight the strength and continued growth of the Dutch gaming market, primarily driven by the growth of iGaming.

However, unions continued to fear that the current regulatory and tax changes would lead to many job losses.

First Look at Some New Las Vegas Resorts

First Look at Some New Las Vegas Resorts

Sin City is always changing! New Las Vegas resorts being built while others are renovated and rebranded… one right in the heart of the Las Vegas Strip! So that’s where we start this week, as we say goodbye to the Cromwell. The hotel is being transformed into a first of its kind destination: The Vanderpump! Renovations will upgrade 188 guest rooms and suites, plus makeover the casino floor. Actress turned restaurant owner Lisa Vanderpump has partnered with Caesar’s on this project after working with them to open a restaurant at the Paris. A cocktail lounge at Caesar’s Palace and Pinkies by Vanderpump at Flamingo. No word just yet on how these changes will impact the popular Interlude Lounge or Dre’s nightclub at Cromwell. But we do know the property will remain open during the transformation, which should be completed in early 2026.

Meanwhile, another of the new Las Vegas resorts and casino is under construction out in Henderson as Boyd Gaming plans to bring Cadence Crossing to the desert. Groundbreaking for this $100 million. Project took place April 3rd, and construction is well underway. Plans for the property include a 10,000 square foot casino with 450 slot machines and various food and drink outlets. Future upgrades will include the construction of a hotel tower and expanded gaming. This property will replace their jokers wild casino, which will be torn down to make room for additional parking. This is Boyd’s first new casino since the East Side Cannery and the Aliante opened in 2008 and Cadence Crossing should be welcoming guests by the middle of next year.

Now we head downtown where the owners of Rolling Stone Magazine want a resort they can call their very own. And to that end, they’re looking to buy the downtown grand. Penske Media wants to open a Rolling Stone branded hotel and casino, and this seems like the place to do it. The company purchased the Life is Beautiful Music and Art Festival a few years ago, which takes place in downtown Vegas. Penske has also worked with Area 15 on the amplified immersive rock experience, and if Downtown Grand does become the Rolling Stone, it would also become the new home for the Life is Beautiful festival.  Penske has been looking to expand the Rolling Stone brand, perhaps following the example set by the Hard Rock model of success.

And speaking of the Hard Rock and Las Vegas, there’s been some major progress transitioning that property from Mirage into the Hard Rock. The Volcano is a distant memory and the new guitar shaped hotel is on the rise. After clearing away the landscaping and removing the atrium and entrance, the main pillars for the hotel tower are now going up. The new Hard Rock Casino will have over 170,000 square feet of floor space with 2000 slot machines and over 200 table games. The Hard Rock Hotel will have over 3000 rooms in the old Mirage Tower, plus another 600 premier rooms in the guitar tower. The property is still on schedule for an opening in early 2027.

Finally this week a quick update on another of the new Las Vegas resorts: The Dream Hotel project located at the south end of Las Vegas Boulevard, which has been under construction since 2021. And now the owners have asked for a two year extension on building permits while they try to get their shit together. Some believe that this resort is already a failure, like the proposed Atari and Majestic hotels. Others believe that eventually, eventually it will be completed, much like the font on blue.

THE NEW LOOK

THE NEW LOOK

From pods to cabinets, the slot floor has come a long way

By Frank Legato

Slot floors just aren’t what they used to be.

When one considers the evolution of the physical slot floor over the past few decades, what reveals itself is a shift in look and feel that first developed because of the changing styles of the games themselves.

When slots experienced their first burst of popularity in the 1980s, the change was not apparent to the naked eye. In the early 1980s, slots became computerized with the “virtual reel” system. The physical reels became nothing more than display mechanisms to show the results of freezing, with each spin, a sequence of numbers, each related to a particular reel result.

What this meant to slot play was that jackpots became larger, because the use of duplicate numbers related to each reel symbol stretched the odds that one would score the highest results. Longer odds meant jackpots that previously topped out under $1,000 could stretch into the tens of thousands, or, in the case of multi-site progressives, the hundreds of thousands and even the millions.

Even with this monumental development, though, the look and the atmosphere of your average slot floor did not change at first. By and large, the machines all looked the same, with three mechanical reels displaying bar combinations, 7s, maybe cherries, and a few wild symbols.

The advent of multi-line video slots in the 1990s provided the first change to the look of the floor. These games were more angular, more boxy, than the mechanical reel-spinners. Video animation now provided a new, distinctive glow to many of the machines. Along with video poker, the slots provided a greater mix of visuals—mechanical reels varying with the glowing video monitors.

While big changes in slot cabinets were still to come, the slot floors of the early 2000s into the mid-2010s maintained one overriding similarity to those earlier floors—the accepted practice of casino slot managers was to cram as many machines onto the floor as would fit. The result was rows and rows of straight slot-machine banks, and an often- uncomfortable crowding of players with their fellow casino-goers.

These were the days when players could often be seen playing two or three machines at once, alternating spins among the games and often hogging large portions of slot banks to themselves.

Over the most recent decade, a few developments completely turned that slot-floor model on its ear.

First, slot manufacturers got really creative with cabinet design. Cabinets with stacked and curved monitors changed the look of the floor. Giant cabinets appeared with bench seats and dual dash buttons. Couples could now play together on one giant machine. The days of players wagering on multiple games at once were suddenly numbered.

Second, the Great Recession of 2008-09 happened. Slot manufacturers began to weed out the slot games that were not making them money. The need to cut costs led to a revelation—casinos could make as much or more money with fewer games.

With this realization, the layout of the slot floor changed. Long banks of like-sized slot machines evolved into a slot floor with a lot more breathing room between games. Instead of navigating a cramped floor crowded with players in a close environment, the floor became a lot more comfortable. Long slot banks were replaced with groupings of back-to-back slots—three, four or six games to a side.

Advancements like cabinets with large, flat button decks and “ergonomic” designs added to the new, relaxed slot atmosphere.

But what really completed the transformation of the slot floor was the Covid-19 pandemic. After months of unprecedented casino shutdowns, slot managers were suddenly faced with the requirement for “social distancing.”

At first, this meant the eminently unsustainable practice of shutting down every other machine. Soon, though, the slot manufacturers provided a much more sensible solution: “pods.”

In the old days, these were called “slot carousels,” and they were the only exception to the straight rows of machines. Slots would be arranged in a circle, with a jackpot prize—a motorcycle, even a car or a boat—sitting on top of the carousel. Pods would bring back the practice of placing machines in a circle.

But now, the machines are spaced so as to give plenty of room to each player. As a result, today’s slot floors, particularly in the newer properties, provide players a comfortable, uncrowded experience that was not possible in the earlier halcyon days of slot popularity.

So use the automated system to order yourself a drink (it sure beats flagging down cocktail servers!), insert your money, sit back, relax, and play your favorite game.

And thank your lucky stars you’re not crowded into a cramped space like in the old days. It’s not your fathers’ slot floor anymore.

How the Sound Burger curbed my vinyl craving with a game-changing audio feature

How the Sound Burger curbed my vinyl craving with a game-changing audio feature

sound-burger-1.jpg

is $25 off, making it cost $174. Note: This discount only applies to the black color. 


Technology is all about embracing the now. So, even though I am one of those people who can be stuck in their ways (such as listening to vinyl records with the appropriate analog setup), I’m glad this time I branched out to see what’s possible.

I recently got my hands on the Audio-Technica Sound Burger

The Sound Burger is easy to set up. I had vinyl playing on the device through a Bluetooth speaker in minutes. My regular vinyl setup is in the basement, so the Sound Burger satiated my craving (pun intended) to listen to vinyl in the living room. I even took it out to my deck one night, and it was fun to vibe out to an original Fleetwood Mac record outside with a fire going.

portability is unparalleled, and this is my favorite Bluetooth turntable because it embodies what Bluetooth was meant for — portability. If you plan to listen to vinyl via Bluetooth, this is how to do it.

Of course, audiophiles or vinyl diehards might argue that this portable player is a waste since portability isn’t the point of vinyl. But hear me out: if we can use technology to take vinyl to the outdoors or on vacation while tucked away in a cabin, why not take it for a spin?

While many sales events feature deals for a specific length of time, deals are on a limited-time basis, making them subject to expire anytime. ZDNET remains committed to finding, sharing, and updating the best offers to help you maximize your savings so you can feel as confident in your purchases as we feel in our recommendations. Our ZDNET team of experts constantly monitors the deals we feature to keep our stories up-to-date. If you missed out on this deal, don’t worry — we’re always sourcing new savings opportunities at ZDNET.com.


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2025 Irish Grand National Ante-Post Tip

2025 Irish Grand National Ante-Post Tip

It feels like a lifetime ago that we backed Lord Lariat to
win the Irish National at 80/1 in 2022. We have come up dry in the last two
renewals but I am hoping that this 100/1 shot can give us a run for our money
after all the rain that has fallen in the last couple of days.

Back in January we backed Macs Charm for the Thyestes Chase
at Gowran. I thought he was well handicapped off 135 and that the ground had
come right for him but he didn’t jump brilliantly and he ended up finishing
eighth, 32l behind the subsequent Aintree National winner Nick Rockett and 8l
behind Yeah Man in fourth.

Weak In The Betting

Given how weak he was in the market that day, just like he
was when finishing seventh in the National Trial at Punchestown last time out, I’m
not sure he was fully wound up for those contests. If he gets into the race on Easter
Monday, which he should do (needs six to come out), surely he’ll be trying his hardest.

The rain that has fallen, with more due to come, is in his favour
and he is now 5lb lower than when winning at this meeting in 2023. He’s also
entered in that race on Monday but surely that’s just a contingency plan in
case he doesn’t get into the big one.

Surprisingly, this will be the first time he has raced at Fairyhouse
since that impressive win and that was the last time he got his head in front. I’m
not sure he wants bottomless ground at this trip but I’d imagine it should be
somewhere between yielding to soft and if it is Macs Charm could outrun his price of 100/1. At those odds, he’s worth chancing e/w for small stakes. Fingers crossed he gets in. 

2025 Irish Grand National Ante-Post Tip: Macs Charm e/w @
100/1 (5 places)

-DaveStevos

2025 Irish Grand National Ante-Post Tip

2025 Irish Grand National Ante-Post Tip

It feels like a lifetime ago that we backed Lord Lariat to
win the Irish National at 80/1 in 2022. We have come up dry in the last two
renewals but I am hoping that this 100/1 shot can give us a run for our money
after all the rain that has fallen in the last couple of days.

Back in January we backed Macs Charm for the Thyestes Chase
at Gowran. I thought he was well handicapped off 135 and that the ground had
come right for him but he didn’t jump brilliantly and he ended up finishing
eighth, 32l behind the subsequent Aintree National winner Nick Rockett and 8l
behind Yeah Man in fourth.

Weak In The Betting

Given how weak he was in the market that day, just like he
was when finishing seventh in the National Trial at Punchestown last time out, I’m
not sure he was fully wound up for those contests. If he gets into the race on Easter
Monday, which he should do (needs six to come out), surely he’ll be trying his hardest.

The rain that has fallen, with more due to come, is in his favour
and he is now 5lb lower than when winning at this meeting in 2023. He’s also
entered in that race on Monday but surely that’s just a contingency plan in
case he doesn’t get into the big one.

Surprisingly, this will be the first time he has raced at Fairyhouse
since that impressive win and that was the last time he got his head in front. I’m
not sure he wants bottomless ground at this trip but I’d imagine it should be
somewhere between yielding to soft and if it is Macs Charm could outrun his price of 100/1. At those odds, he’s worth chancing e/w for small stakes. Fingers crossed he gets in. 

2025 Irish Grand National Ante-Post Tip: Macs Charm e/w @
100/1 (5 places)

-DaveStevos

The New Era of Secure and Instant Payments in Online Betting

The methods of financing digital betting show rapid expansion at Betway. The development of the online casino and gaming industry creates novel payment methods which provide faster and better security, together with increased convenience for users.

Here are several new payment patterns that might impact internet-based gambling payments in the upcoming years.

Digital Wallet Domination

The digital financial world is shifting toward digital wallet solutions at a global level. Database industry sport betting activity shows 79% adoption rates, and the figures state that they could even reach around 83%. The usage rates in certain nations remain low, but younger generations demonstrate increasing interest in digital payment methods that provide mobile solutions.

Users base their selection on security features because these features rank as their primary concern in choosing their online wallets.

Innovations In Identification Verification

Biometric authentication stands as an established advancement that multiple organizations use for identity management purposes. Up-To-Date smartphones integrate fingerprint readers as well as facial identity detection, and select devices have additional voice pattern identification capability. Your betting site authentication becomes safer through these solutions, which allow you to enjoy both security and comfort. Biometric systems lower security risks since they provide protection through an unequaled authentication method which cannot be reproduced.

Improved Security For Safer Payments

Security has emerged as a substantial concern because of increasing online gaming payment transactions. Casinos protect payments through the combination of three-factor authentication systems, which include two-factor authentication (2FA) and encryption alongside fingerprint and facial recognition security. Online gaming users obtain greater trust through security features that safeguard their personal information.

Due to the evolution of cyber threats, lawmakers demand casinos to enhance their sophisticated security systems constantly. Payment methods that prioritize both user privacy and safety will be the choice that wins out in the end.

AI-Driven Fraud Detection

Real-time fraudulent operation detection emerges as a key functionality that artificial intelligence (AI) strategies progressively deliver. The evaluation capabilities of AI systems enable them to detect suspicious activities in sport betting transactions, which then leads to stopping fraudulent activity before it happens. Secure online betting payments will go through a revolutionary transformation with these developments.

Cryptocurrency Is Here to Stay

A variety of cryptocurrencies, such as Bitcoin alongside Ethereum, are now accepted as payment methods by online casinos, and specific platforms have already integrated this payment functionality. The new payment option provides gamers enhanced privacy, together with rapid processing speeds, and it costs less while offering better security than basic payment systems. Instantaneous transactions happen through the use of cryptocurrency, thus providing quick service, which would benefit players who need their transactions processed swiftly.

The expanding digital currency adoption rate likely encourages casinos to embrace new payment options because certain platforms provide advantages to their users if they use these digital payment platforms. Users of cryptocurrency for gambling might soon benefit from transactions that occur faster and come at lower fees due to its increasing adoption rate in this field.

Evolving Payment Security for a New Era of Online Betting

Virtual gambling houses adopt payment methods that are continuously evolving because cryptocurrency and mobile wallet transactions, together with enhanced data protection systems, will likely persist. The system gives gamers easy and secure transaction options that can be executed quickly at Betway. Casinos must remain cautious because technological advancements will compel them to enable the most current services in this progressively transforming industry.

Kaufland expands: ‘From Europe, for Europe’

Kaufland expands: ‘From Europe, for Europe’

Kaufland will open its marketplace to consumers in France and Italy by the end of the summer. “We are the alternative to global ecommerce giants, from Europe for Europe. With that goal in mind, we are now taking the next two steps – certainly not the last”, according to Gerald Schönbucher, CEO of Kaufland e-commerce.

1World Online Announces TravelVerse Launch at Expo 2025 in Osaka

Apr 12, 2025

1World Online is proud to announce that its flagship product, TravelVerse, will be featured at Expo 2025 in Osaka, Japan – one of the world’s most prestigious global events, expected to draw over 28 million visitors.

TravelVerse is a real-world application of Web3 technology. It uses NFTs as digital vouchers and proof of visit, while smart contracts and onchain storage ensure long-term digital presence and meaningful engagement. Built for the tourism sector, cultural institutions, and event organizers, TravelVerse acts as a digital layer that expands the horizon of reality – connecting physical places with immersive digital content.

TravelVerse is actively used across European and Middle Eastern pavilions at Expo 2025, providing visitors with immersive, interactive tour experiences. Visit our web application to learn more about TravelVerse Expo 2025.

In addition to its global reach, TravelVerse is creating opportunities for everyone to contribute and be part of this groundbreaking experience. Through our Contribution Panel, users from around the world can submit Points of Interest (POIs) combining them into custom Tours and share their unique perspectives on cultural landmarks, tourism sites, and events. These contributions and user-inspired NFTs can be stored permanently on the blockchain, preserving information about valuable artifacts and destinations for future generations. Everyone is invited to participate and help create a new digital layer of the tourism ecosystem.

Join now and contribute to the growing collection of experiences on TravelVerse.

As part of its strategic expansion, 1World Online is entering new regional partnerships to scale TravelVerse’s adoption across Europe and beyond. A key collaboration has been established with UP Capital Management, a forward-thinking investment and development firm covering the Web3 and AI sectors.

“Our partnership with UP Capital Management is a major step forward for TravelVerse,” said Alex Fedosseev, Founder and CEO of 1World Online. “We are planning to combine our Web3 technology expertise with their deep market access and strategic business development approach to accelerate TravelVerse’s reach across industries – from culture and tourism to real estate and innovations.”

“We are very excited to work with 1World Online on their product TravelVerse – as one of the leaders in bringing tourism and culture to the world through the power of Web3 and AI.” – says James Pope, COO of UP Capital Management.

For more information on partnership or press inquiries, please contact:

1World Online / TravelVerse project
Lucy Bronnikova

Marketing Manager
marketing@1worldonline.com
+43 677 64721316

travelverse.live

UP Capital Management
Robin Volbers
Director – Special Situations & Strategic Projects (VC/PE/PD)
robin.volbers@up-cm.com
+41 79 758-6035
www.up-cs.com